Frontiers in Transplantation (Oct 2023)
Supercooling: a promising technique for prolonged preservation in solid organ transplantation, and early perspectives in vascularized composite allografts
- Yanis Berkane,
- Yanis Berkane,
- Yanis Berkane,
- Yanis Berkane,
- Justine Hayau,
- Irina Filz von Reiterdank,
- Irina Filz von Reiterdank,
- Irina Filz von Reiterdank,
- Irina Filz von Reiterdank,
- Anil Kharga,
- Anil Kharga,
- Laura Charlès,
- Laura Charlès,
- Abele B. Mink van der Molen,
- J. Henk Coert,
- Nicolas Bertheuil,
- Nicolas Bertheuil,
- Mark A. Randolph,
- Mark A. Randolph,
- Curtis L. Cetrulo,
- Curtis L. Cetrulo,
- Alban Longchamp,
- Alban Longchamp,
- Alban Longchamp,
- Alban Longchamp,
- Alexandre G. Lellouch,
- Alexandre G. Lellouch,
- Korkut Uygun,
- Korkut Uygun,
- Korkut Uygun
Affiliations
- Yanis Berkane
- Vascularized Composite Allotransplantation Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
- Yanis Berkane
- Shriners Children’s Boston, Harvard Medical School, Boston, MA, United States
- Yanis Berkane
- Department of Plastic, Reconstructive and Aesthetic Surgery, Hôpital Sud, CHU Rennes, University of Rennes, Rennes, France
- Yanis Berkane
- MOBIDIC, UMR INSERM 1236, Rennes University Hospital, Rennes, France
- Justine Hayau
- Division of Plastic Surgery, Lausanne University Hospital, Lausanne, Switzerland
- Irina Filz von Reiterdank
- Vascularized Composite Allotransplantation Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
- Irina Filz von Reiterdank
- Shriners Children’s Boston, Harvard Medical School, Boston, MA, United States
- Irina Filz von Reiterdank
- Department of Plastic, Reconstructive and Hand Surgery, University Medical Center Utrecht, Utrecht, Netherlands
- Irina Filz von Reiterdank
- Center for Engineering for Medicine and Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
- Anil Kharga
- Shriners Children’s Boston, Harvard Medical School, Boston, MA, United States
- Anil Kharga
- Center for Engineering for Medicine and Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
- Laura Charlès
- Vascularized Composite Allotransplantation Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
- Laura Charlès
- Shriners Children’s Boston, Harvard Medical School, Boston, MA, United States
- Abele B. Mink van der Molen
- Department of Plastic, Reconstructive and Hand Surgery, University Medical Center Utrecht, Utrecht, Netherlands
- J. Henk Coert
- Department of Plastic, Reconstructive and Hand Surgery, University Medical Center Utrecht, Utrecht, Netherlands
- Nicolas Bertheuil
- Department of Plastic, Reconstructive and Aesthetic Surgery, Hôpital Sud, CHU Rennes, University of Rennes, Rennes, France
- Nicolas Bertheuil
- MOBIDIC, UMR INSERM 1236, Rennes University Hospital, Rennes, France
- Mark A. Randolph
- Vascularized Composite Allotransplantation Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
- Mark A. Randolph
- Shriners Children’s Boston, Harvard Medical School, Boston, MA, United States
- Curtis L. Cetrulo
- Vascularized Composite Allotransplantation Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
- Curtis L. Cetrulo
- Shriners Children’s Boston, Harvard Medical School, Boston, MA, United States
- Alban Longchamp
- Shriners Children’s Boston, Harvard Medical School, Boston, MA, United States
- Alban Longchamp
- Center for Engineering for Medicine and Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
- Alban Longchamp
- Department of Vascular Surgery, Lausanne University Hospital, Lausanne, Switzerland
- Alban Longchamp
- Center for Transplant Sciences, Massachusetts General Hospital, Boston, MA, United States
- Alexandre G. Lellouch
- Vascularized Composite Allotransplantation Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
- Alexandre G. Lellouch
- Shriners Children’s Boston, Harvard Medical School, Boston, MA, United States
- Korkut Uygun
- Shriners Children’s Boston, Harvard Medical School, Boston, MA, United States
- Korkut Uygun
- Center for Engineering for Medicine and Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
- Korkut Uygun
- Center for Transplant Sciences, Massachusetts General Hospital, Boston, MA, United States
- DOI
- https://doi.org/10.3389/frtra.2023.1269706
- Journal volume & issue
-
Vol. 2
Abstract
Ex vivo preservation of transplanted organs is undergoing spectacular advances. Machine perfusion is now used in common practice for abdominal and thoracic organ transportation and preservation, and early results are in favor of substantially improved outcomes. It is based on decreasing ischemia-reperfusion phenomena by providing physiological or sub-physiological conditions until transplantation. Alternatively, supercooling techniques involving static preservation at negative temperatures while avoiding ice formation have shown encouraging results in solid organs. Here, the rationale is to decrease the organ's metabolism and need for oxygen and nutrients, allowing for extended preservation durations. The aim of this work is to review all advances of supercooling in transplantation, browsing the literature for each organ. A specific objective was also to study the initial evidence, the prospects, and potential applications of supercooling preservation in Vascularized Composite Allotransplantation (VCA). This complex entity needs a substantial effort to improve long-term outcomes, marked by chronic rejection. Improving preservation techniques is critical to ensure the favorable evolution of VCAs, and supercooling techniques could greatly participate in these advances.
Keywords
- supercooling
- subzero
- organ preservation
- VCA
- vascularized composite allotransplantation
- machine perfusion
