Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis

Ashley C. Bolte; Arun B. Dutta; Mariah E. Hurt; Igor Smirnov; Michael A. Kovacs; Celia A. McKee; Hannah E. Ennerfelt; Daniel Shapiro; Bao H. Nguyen; Elizabeth L. Frost; Catherine R. Lammert; Jonathan Kipnis; John R. Lukens

doi:10.1038/s41467-020-18113-4

Nature Communications (Sep 2020)

Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis

Ashley C. Bolte,
Arun B. Dutta,
Mariah E. Hurt,
Igor Smirnov,
Michael A. Kovacs,
Celia A. McKee,
Hannah E. Ennerfelt,
Daniel Shapiro,
Bao H. Nguyen,
Elizabeth L. Frost,
Catherine R. Lammert,
Jonathan Kipnis,
John R. Lukens

Affiliations

Ashley C. Bolte: Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia
Arun B. Dutta: Medical Scientist Training Program, University of Virginia
Mariah E. Hurt: Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia
Igor Smirnov: Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia
Michael A. Kovacs: Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia
Celia A. McKee: Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia
Hannah E. Ennerfelt: Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia
Daniel Shapiro: Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia
Bao H. Nguyen: Department of Biochemistry and Molecular Genetics, University of Virginia
Elizabeth L. Frost: Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia
Catherine R. Lammert: Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia
Jonathan Kipnis: Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia
John R. Lukens: Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia

DOI: https://doi.org/10.1038/s41467-020-18113-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 18

Abstract

Read online

Traumatic brain injury (TBI) is a serious and poorly understood medical condition. Here, the authors show that TBI induces long-lasting deficits in brain lymphatic drainage. They report that defects in this drainage pathway provoke severe TBI pathogenesis that can be rescued with VEGF-C treatment.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal