<i>Pinus halepensis</i> Essential Oil Ameliorates Aβ1-42-Induced Brain Injury by Diminishing Anxiety, Oxidative Stress, and Neuroinflammation in Rats
Paula Alexandra Postu,
Marius Mihasan,
Dragos Lucian Gorgan,
Fatima Zahra Sadiki,
Mostafa El Idrissi,
Lucian Hritcu
Affiliations
Paula Alexandra Postu
Center for Fundamental Research and Experimental Development in Translation Medicine–TRANSCEND, Regional Institute of Oncology, 7000483 Iasi, Romania
Marius Mihasan
Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, Romania
Dragos Lucian Gorgan
Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, Romania
Fatima Zahra Sadiki
Laboratory of Molecular Chemistry and Natural Substances, Department of Chemistry, Faculty of Sciences of Meknes, Moulay Ismail University, Meknès 11201, Morocco
Mostafa El Idrissi
Laboratory of Molecular Chemistry and Natural Substances, Department of Chemistry, Faculty of Sciences of Meknes, Moulay Ismail University, Meknès 11201, Morocco
Lucian Hritcu
Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, Romania
The Pinus L. genus comprises around 250 species, being popular worldwide for their medicinal and aromatic properties. The present study aimed to evaluate the P. halepensis Mill. essential oil (PNO) in an Alzheimer’s disease (AD) environment as an anxiolytic and antidepressant agent. The AD-like symptoms were induced in Wistar male rats by intracerebroventricular administration of amyloid beta1-42 (Aβ1-42), and PNO (1% and 3%) was delivered to Aβ1-42 pre-treated rats via inhalation route for 21 consecutive days, 30 min before behavioral assessments. The obtained results indicate PNO’s potential to relieve anxious–depressive features and to restore redox imbalance in the rats exhibiting AD-like neuropsychiatric impairments. Moreover, PNO presented beneficial effects against neuroinflammation and neuroapoptosis in the Aβ1-42 rat AD model.
