Clinical, Cosmetic and Investigational Dermatology (Oct 2022)
Long-Term Use of Antiperspirant is Associated with a Low Risk of Postoperative Complications in Patients with Axillary Osmidrosis
Abstract
Wen-Tsao Ho,1,* Chin-Yi Yang,2– 4,* Ming-Feng Tsai5– 7 1Department of Dermatology, Ho Wen Tsao Skin Clinic, New Taipei City, 244, Taiwan; 2Department of Dermatology, New Taipei Municipal TuCheng Hospital, New Taipei City, 236, Taiwan; 3Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, 333, Taiwan; 4Department of Cosmetic Science, Chang Gung University of Science and Technology, Linkou, Taoyuan, 333, Taiwan; 5Division of Plastic Surgery, Department of Surgery, Mackay Memorial Hospital, Taipei City, 104, Taiwan; 6Department of Medicine, MacKay Medical College, New Taipei, 25245, Taiwan; 7Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei City, 110, Taiwan*These authors contributed equally to this workCorrespondence: Ming-Feng Tsai, Division of Plastic Surgery, Department of Surgery, Mackay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Road, Zhongshan Dist, Taipei City, 104, Taiwan, Tel +886-2-2543-3535, Fax +886-2-2543-3642, Email [email protected]: Many patients with axillary osmidrosis (AO) cannot tolerate the local irritation of strong antiperspirants and discontinue AO use within a short time. This study evaluates the effect of long-term antiperspirant use on postoperative complications after osmidrosis surgery.Patients and Methods: A total of 116 females (66 antiperspirant and 50 non-antiperspirant cases) who underwent osmidrosis surgery were retrospectively reviewed. Postoperative complications were compared between the 2 groups.Results: Patients with long-term antiperspirant use had a lower risk of full-thickness skin necrosis compared with those who did not use antiperspirants (odds ratio [OR] = 0.048, 95% confidence Interval [CI]: 0.006– 0.392, p = 0.005). Patients with antiperspirants use also had a lower risk of moderate-to-severe erythema compared to those without antiperspirants use (moderate vs mild erythema: OR = 0.351, 95% CI: 0.129– 0.959, p = 0.041; severe vs mild erythema: OR = 0.161, 95% CI: 0.047– 0.550, p = 0.004). Patients who used antiperspirants also had a lower risk of severe skin erosion compared to those who did not use antiperspirants (severe vs mild skin erosion: OR = 0.164, 95% CI: 0.037– 0.725, p = 0.017). There was a trend of lower risk in moderate skin erosion in patients with antiperspirant use compared to those without antiperspirant use, but it was not statistically significant (moderate vs mild epidermal damage and peeling: OR = 0.406, 95% CI: 0.158– 1.043, p = 0.061).Conclusion: Postoperative complications in patients with AO who undergo osmidrosis surgery are lower in those with a long-term antiperspirant use compared to patients who did not use antiperspirants.Keywords: axillary osmidrosis, antiperspirant, complications, surgery
