Discontinuation of HIIT restores diabesity while retraining increases gut microbiota diversity
Filipe Moura Ribeiro,
Bernardo Petriz,
Maycon Anderson,
Victoria Assis,
Thiago Rosa dos Santos,
Hugo Correa,
Nathalia Cavichiolli de Oliveira,
Lana Passos,
Amanda Fonseca,
Luiz Arnaldo Brito,
Osmar Silva,
Alinne Castro,
Octavio Luiz Franco
Affiliations
Filipe Moura Ribeiro
Center for Proteomics and Biochemical Analysis, Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, DF, Brazil; Postgraduate Program in Physical Education, Catholic University of Brasília, Brasília, DF, Brazil; Laboratory of Molecular Exercise Physiology, University Center, Brasília, DF, Brazil
Bernardo Petriz
Center for Proteomics and Biochemical Analysis, Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, DF, Brazil; Laboratory of Molecular Exercise Physiology, University Center, Brasília, DF, Brazil; Postgraduate Program in Biotechnology, S-Inova Biotech, Dom Bosco Catholic University, Campo Grande, MS, Brazil
Maycon Anderson
Center for Proteomics and Biochemical Analysis, Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, DF, Brazil; Laboratory of Molecular Exercise Physiology, University Center, Brasília, DF, Brazil
Victoria Assis
Laboratory of Molecular Exercise Physiology, University Center, Brasília, DF, Brazil; Laboratory of Molecular Analysis, Postgraduate Program of Sciences and Technology of Health, University of Brasilia, Brasília, DF, Brazil
Thiago Rosa dos Santos
Center for Proteomics and Biochemical Analysis, Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, DF, Brazil; Postgraduate Program in Physical Education, Catholic University of Brasília, Brasília, DF, Brazil
Hugo Correa
Postgraduate Program in Physical Education, Catholic University of Brasília, Brasília, DF, Brazil
Nathalia Cavichiolli de Oliveira
Postgraduate Program in Biotechnology, S-Inova Biotech, Dom Bosco Catholic University, Campo Grande, MS, Brazil
Lana Passos
Center for Proteomics and Biochemical Analysis, Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, DF, Brazil; Laboratory of Molecular Exercise Physiology, University Center, Brasília, DF, Brazil
Amanda Fonseca
Center for Proteomics and Biochemical Analysis, Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, DF, Brazil; Laboratory of Molecular Exercise Physiology, University Center, Brasília, DF, Brazil
Luiz Arnaldo Brito
Center for Proteomics and Biochemical Analysis, Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, DF, Brazil; Laboratory of Molecular Exercise Physiology, University Center, Brasília, DF, Brazil
Osmar Silva
Postgraduate Program in Pharmaceutical Sciences, Universidade Evangélica de Goiás, UniEVANGÉLICA, Goiás, GO, Brazil
Alinne Castro
Postgraduate Program in Biotechnology, S-Inova Biotech, Dom Bosco Catholic University, Campo Grande, MS, Brazil
Octavio Luiz Franco
Center for Proteomics and Biochemical Analysis, Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília, DF, Brazil; Postgraduate Program in Physical Education, Catholic University of Brasília, Brasília, DF, Brazil; Postgraduate Program in Biotechnology, S-Inova Biotech, Dom Bosco Catholic University, Campo Grande, MS, Brazil; Corresponding author
Summary: Investigations involving high-intensity interval training (HIIT) have proven to be efficient in controlling diabesity. This study aimed to assess the impact of discontinuing HIIT and retraining within the context of diabesity. 75 C57BL6 mice went through 5 stages: baseline, induction of diabesity with Western diet, training, detraining, and retraining (6 weeks each period). Detraining led to elevated adiposity, exacerbated metabolic parameters and intestinal health, and altered gut microbiota composition. Retraining restored blood glucose regulation and enhanced intestinal health yet did not induce fat reduction. While both training and retraining exerted an effect on the composition of the gut microbiota, the impact of diet demonstrates a more substantial potency compared to that of exercise concerning intestinal health and microbiome. These findings may contribute to a broader understanding of diabesity management and introduce perspectives for the use of specific physical training to enhance patient outcomes and intestine health.
