Advances and current concepts on Eph receptors and ephrins in upper digestive tract cancers

Luccas Lavareze; Luccas Lavareze; Talita de Carvalho Kimura; Talita de Carvalho Kimura; João Figueira Scarini; João Figueira Scarini; Reydson Alcides de Lima-Souza; Reydson Alcides de Lima-Souza; Moisés Willian Aparecido Gonçalves; Moisés Willian Aparecido Gonçalves; Raisa Sales de Sá; Raisa Sales de Sá; Iara Gonçalves Aquino; Iara Gonçalves Aquino; Patricia Maria Fernandes; Fernanda Cristina Poscai Ribeiro; Albina Altemani; Fernanda Viviane Mariano; Gary Chris Fillmore; Erika Said Abu Egal; Erika Said Abu Egal

doi:10.3389/fonc.2024.1520306

Frontiers in Oncology (Jan 2025)

Advances and current concepts on Eph receptors and ephrins in upper digestive tract cancers

Luccas Lavareze,
Luccas Lavareze,
Talita de Carvalho Kimura,
Talita de Carvalho Kimura,
João Figueira Scarini,
João Figueira Scarini,
Reydson Alcides de Lima-Souza,
Reydson Alcides de Lima-Souza,
Moisés Willian Aparecido Gonçalves,
Moisés Willian Aparecido Gonçalves,
Raisa Sales de Sá,
Raisa Sales de Sá,
Iara Gonçalves Aquino,
Iara Gonçalves Aquino,
Patricia Maria Fernandes,
Fernanda Cristina Poscai Ribeiro,
Albina Altemani,
Fernanda Viviane Mariano,
Gary Chris Fillmore,
Erika Said Abu Egal,
Erika Said Abu Egal

Affiliations

Luccas Lavareze: Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
Luccas Lavareze: Department of Oral Diagnosis, Piracicaba School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, São Paulo, Brazil
Talita de Carvalho Kimura: Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
Talita de Carvalho Kimura: Department of Oral Diagnosis, Piracicaba School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, São Paulo, Brazil
João Figueira Scarini: Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
João Figueira Scarini: Department of Oral Diagnosis, Piracicaba School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, São Paulo, Brazil
Reydson Alcides de Lima-Souza: Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
Reydson Alcides de Lima-Souza: Department of Oral Diagnosis, Piracicaba School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, São Paulo, Brazil
Moisés Willian Aparecido Gonçalves: Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
Moisés Willian Aparecido Gonçalves: Department of Oral Diagnosis, Piracicaba School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, São Paulo, Brazil
Raisa Sales de Sá: Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
Raisa Sales de Sá: Department of Oral Diagnosis, Piracicaba School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, São Paulo, Brazil
Iara Gonçalves Aquino: Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
Iara Gonçalves Aquino: Department of Oral Diagnosis, Piracicaba School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, São Paulo, Brazil
Patricia Maria Fernandes: Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
Fernanda Cristina Poscai Ribeiro: Department of Internal Medicine, University of Western São Paulo (UNOESTE), Guarujá, São Paulo, Brazil
Albina Altemani: Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
Fernanda Viviane Mariano: Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
Gary Chris Fillmore: Biorepository and Molecular Pathology, Huntsman Cancer Institute, University of Utah (UU), Salt Lake City, UT, United States
Erika Said Abu Egal: Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
Erika Said Abu Egal: Biorepository and Molecular Pathology, Huntsman Cancer Institute, University of Utah (UU), Salt Lake City, UT, United States

DOI: https://doi.org/10.3389/fonc.2024.1520306
Journal volume & issue: Vol. 14

Abstract

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Erythropoietin-producing hepatocellular (Eph) receptors comprise the largest group of surface receptors and are responsible for cellular signals. Eph/ephrin signaling has been identified to play a role in key cancer development and progression processes, especially in the upper gastrointestinal tract. The Eph/ephrin system has been described as a tumor suppressor in duodenal cancer, while in esophageal, gastric, hepatic, and pancreatic cancer, the system has been related to tumor progression. For their significant role in developing a wide range of malignancies, Eph receptors and their ligands have proven to be an important target for new anticancer therapies. In this review, we present an overview of the literature and highlight evidence supporting the role of the Eph/ephrin system in upper digestive tract cancers. In addition, we discuss molecular findings that represent promising therapeutic targets for these cancers.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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