Frontiers in Endocrinology (Jun 2023)

Association between remnant cholesterol and chronic kidney disease in Chinese hypertensive patients

  • Ting Yuan,
  • Ting Yuan,
  • Ting Yuan,
  • Congcong Ding,
  • Congcong Ding,
  • Congcong Ding,
  • Yanyou Xie,
  • Yanyou Xie,
  • Yanyou Xie,
  • Xinlei Zhou,
  • Xinlei Zhou,
  • Xinlei Zhou,
  • Chong Xie,
  • Chong Xie,
  • Chong Xie,
  • Tao Wang,
  • Tao Wang,
  • Tao Wang,
  • Chao Yu,
  • Chao Yu,
  • Chao Yu,
  • Wei Zhou,
  • Wei Zhou,
  • Wei Zhou,
  • Lingjuan Zhu,
  • Lingjuan Zhu,
  • Lingjuan Zhu,
  • Huihui Bao,
  • Huihui Bao,
  • Huihui Bao,
  • Huihui Bao,
  • Xiaoshu Cheng,
  • Xiaoshu Cheng,
  • Xiaoshu Cheng,
  • Xiaoshu Cheng

DOI
https://doi.org/10.3389/fendo.2023.1189574
Journal volume & issue
Vol. 14

Abstract

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BackgroundRemnant cholesterol (RC) and chronic kidney disease (CKD) have not been definitively linked in individuals with different characteristics. This study aims to investigate the relationship between serum RC level and CKD and examine possible effect modifiers in Chinese patients with hypertension.MethodsOur study is based on the Chinese H-type Hypertension Project, which is an observational registry study conducted in real-world settings. The outcome was CKD, defined as an estimated glomerular filtration rate of less than 60 ml/min·1.73 m2. Multivariate logistic regression and smooth curve fitting were used to analyze the association between RC and CKD. Subgroup analyses were subsequently conducted to examine the effects of other variables.ResultsThe mean age of the 13,024 patients with hypertension at baseline was 63.8 ± 9.4 years, and 46.8% were male. A conspicuous linear positive association was observed between RC level and CKD (per SD increment; odds ratio [OR], 1.15; 95% confidence interval [CI], 1.08–1.23). Compared with the lowest quartile group of RC, the risk of CKD was 53% higher (OR, 1.53; 95% CI, 1.26–1.86) in the highest quartile group. Furthermore, a stronger positive association between RC level and CKD was found among participants with a higher body mass index (BMI <24 vs. ≥24 kg/m2; P-interaction = 0.034) or current non-smokers (smoker vs. non-smoker; P-interaction = 0.024).ConclusionsAmong Chinese adults with hypertension, RC level was positively associated with CKD, particularly in those with a BMI of ≥24 kg/m2 and current non-smokers. These findings may help improve lipid management regimens in patients with hypertension.

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