Nature Communications (Sep 2019)

Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells

  • Lei Tan,
  • Lauretta A. Lacko,
  • Ting Zhou,
  • Delia Tomoiaga,
  • Romulo Hurtado,
  • Tuo Zhang,
  • Ana Sevilla,
  • Aaron Zhong,
  • Christopher E Mason,
  • Scott Noggle,
  • Todd Evans,
  • Heidi Stuhlmann,
  • Robert E. Schwartz,
  • Shuibing Chen

DOI
https://doi.org/10.1038/s41467-019-12063-2
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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Here, using human cells and mouse models, the authors show that Zika virus can infect preimplantation trophectoderm. Pre-implantation infection can affect nervous system development and survival of neural progenitors, and can result in miscarriage or spontaneous abortion.