Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss

Andrew Clark; Subhadip Ghatak; Poornachander Reddy Guda; Mohamed S. El Masry; Yi Xuan; Amy Y. Sato; Teresita Bellido; Chandan K. Sen

doi:10.1038/s41536-022-00259-y

npj Regenerative Medicine (Oct 2022)

Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss

Andrew Clark,
Subhadip Ghatak,
Poornachander Reddy Guda,
Mohamed S. El Masry,
Yi Xuan,
Amy Y. Sato,
Teresita Bellido,
Chandan K. Sen

Affiliations

Andrew Clark: Indiana Center for Regenerative Medicine and Engineering, Indiana University Health Comprehensive Wound Center, Department of Surgery, Indiana University School of Medicine
Subhadip Ghatak: Indiana Center for Regenerative Medicine and Engineering, Indiana University Health Comprehensive Wound Center, Department of Surgery, Indiana University School of Medicine
Poornachander Reddy Guda: Indiana Center for Regenerative Medicine and Engineering, Indiana University Health Comprehensive Wound Center, Department of Surgery, Indiana University School of Medicine
Mohamed S. El Masry: Indiana Center for Regenerative Medicine and Engineering, Indiana University Health Comprehensive Wound Center, Department of Surgery, Indiana University School of Medicine
Yi Xuan: Indiana Center for Regenerative Medicine and Engineering, Indiana University Health Comprehensive Wound Center, Department of Surgery, Indiana University School of Medicine
Amy Y. Sato: Department of Anatomy and Cell Biology, Indiana University School of Medicine
Teresita Bellido: Department of Anatomy and Cell Biology, Indiana University School of Medicine
Chandan K. Sen: Indiana Center for Regenerative Medicine and Engineering, Indiana University Health Comprehensive Wound Center, Department of Surgery, Indiana University School of Medicine

DOI: https://doi.org/10.1038/s41536-022-00259-y
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 6

Abstract

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Abstract This work rests on our non-viral tissue nanotransfection (TNT) platform to deliver MyoD (TNTMyoD) to injured tissue in vivo. TNTMyoD was performed on skin and successfully induced expression of myogenic factors. TNTMyoD was then used as a therapy 7 days following volumetric muscle loss (VML) of rat tibialis anterior and rescued muscle function. TNTMyoD is promising as VML intervention.

Published in npj Regenerative Medicine

ISSN: 2057-3995 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://www.nature.com/npjregenmed/

About the journal