Resting-State Functional Magnetic Resonance Imaging and Functional Connectivity Density Mapping in Patients With Optic Neuritis

Ke Song; Yong Wang; Mei-Xia Ren; Jiao Li; Ting Su; Ting Su; Si-Yi Chen; Yi Shao; Ya-Li Lv

doi:10.3389/fnins.2021.718973

Frontiers in Neuroscience (Oct 2021)

Resting-State Functional Magnetic Resonance Imaging and Functional Connectivity Density Mapping in Patients With Optic Neuritis

Ke Song,
Yong Wang,
Mei-Xia Ren,
Jiao Li,
Ting Su,
Ting Su,
Si-Yi Chen,
Yi Shao,
Ya-Li Lv

Affiliations

Ke Song: Department of Equipment, Xi’an People’s Hospital, Xi’an Fourth Hospital, Xi’an, China
Yong Wang: Department of Ophthalmology, Xi’an People’s Hospital, Xi’an Fourth Hospital, Xi’an, China
Mei-Xia Ren: Department of Ophthalmology, Xi’an People’s Hospital, Xi’an Fourth Hospital, Xi’an, China
Jiao Li: Department of Ophthalmology, Xi’an People’s Hospital, Xi’an Fourth Hospital, Xi’an, China
Ting Su: Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Eye Institute of Xiamen University, Medical College of Xiamen University, Xiamen, China
Ting Su: Department of Ophthalmology, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, United States
Si-Yi Chen: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, China
Yi Shao: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, China
Ya-Li Lv: Department of Neurology, Xi’an People’s Hospital, Xi’an Fourth Hospital, Xi’an, China

DOI: https://doi.org/10.3389/fnins.2021.718973
Journal volume & issue: Vol. 15

Abstract

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Background: Using resting-state functional connectivity (rsFC), we investigated alternations in spontaneous brain activities reflected by functional connectivity density (FCD) in patients with optic neuritis (ON).Methods: We enrolled 28 patients with ON (18 males, 10 females) and 24 healthy controls (HCs; 16 males, 8 females). All subjects underwent functional magnetic resonance imaging (fMRI) in a quiet state to determine the values of rsFC, long-range FCD (longFCD), and short-range FCD (IFCD). Receiver operating characteristic (ROC) curves were generated to distinguish patients from HCs.Results: The ON group exhibited obviously lower longFCD values in the left inferior frontal gyrus triangle, the right precuneus and the right anterior cingulate, and paracingulate gyri/median cingulate and paracingulate gyri. The left median cingulate and paracingulate gyri and supplementary motor area (SMA) were also significantly lower. Obviously reduced IFCD values were observed in the left middle temporal gyrus/angular gyrus/SMA and right cuneus/SMA compared with HCs.Conclusion: Abnormal neural activities were found in specific brain regions in patients with ON. Specifically, they showed significant changes in rsFC, longFCD, and IFCD values. These may be useful to identify the specific mechanism of change in brain function in ON.

Published in Frontiers in Neuroscience

ISSN: 1662-4548 (Print); 1662-453X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/neuroscience

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