Nature Communications (May 2019)

Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3

  • Tim Schneider,
  • Lee-Hsueh Hung,
  • Masood Aziz,
  • Anna Wilmen,
  • Stephanie Thaum,
  • Jacqueline Wagner,
  • Robert Janowski,
  • Simon Müller,
  • Silke Schreiner,
  • Peter Friedhoff,
  • Stefan Hüttelmaier,
  • Dierk Niessing,
  • Michael Sattler,
  • Andreas Schlundt,
  • Albrecht Bindereif

DOI
https://doi.org/10.1038/s41467-019-09769-8
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 18

Abstract

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Multidomain RNA-binding proteins recognize specific target sequences through mechanisms that are not well understood. Here the authors present an integrated approach to define the RNA-binding specificity and RNP topology and apply it to the analysis of the prototypical multidomain RNA-binding protein IMP3.