Structure units oriented approach towards collective synthesis of sarpagine-ajmaline-koumine type alkaloids

Wen Chen; Yonghui Ma; Wenyan He; Yinxia Wu; Yuancheng Huang; Yipeng Zhang; Hongchang Tian; Kai Wei; Xiaodong Yang; Hongbin Zhang

doi:10.1038/s41467-022-28535-x

Nature Communications (Feb 2022)

Structure units oriented approach towards collective synthesis of sarpagine-ajmaline-koumine type alkaloids

Wen Chen,
Yonghui Ma,
Wenyan He,
Yinxia Wu,
Yuancheng Huang,
Yipeng Zhang,
Hongchang Tian,
Kai Wei,
Xiaodong Yang,
Hongbin Zhang

Affiliations

Wen Chen: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University
Yonghui Ma: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University
Wenyan He: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University
Yinxia Wu: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University
Yuancheng Huang: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University
Yipeng Zhang: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University
Hongchang Tian: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University
Kai Wei: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University
Xiaodong Yang: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University
Hongbin Zhang: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University

DOI: https://doi.org/10.1038/s41467-022-28535-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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The sarpagine-ajmaline-koumine type alkaloids are among the most important groups of monoterpenoid indole alkaloids, having notable biological activity. Here the authors perform divergent syntheses of 14 natural products in this family from a common intermediate.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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