Frontiers in Neuroscience (Jun 2018)
Globally Normal Bistable Motion Perception of Anisometropic Amblyopes May Profit From an Unusual Coding Mechanism
Abstract
Anisometropic amblyopia is a neurodevelopmental disorder of the visual system. There is evidence that the neural deficits spread across visual areas, from the primary cortex up to higher brain areas, including motion coding structures such as MT. Here, we used bistable plaid motion to investigate changes in the underlying mechanisms of motion integration and segmentation and, thus, help us to unravel in more detail deficits in the amblyopic visual motion system. Our results showed that (1) amblyopes globally exhibited normal bistable perception in all viewing conditions compared to the control group and (2) decreased contrast led to a stronger increase in percept switches and decreased percept durations in the control group, while the amblyopic group exhibited no such changes. There were few differences in outcomes dependent upon the use of the weak eye, the strong eye, or both eyes for viewing the stimuli, but this was a general effect present across all subjects, not specific to the amblyopic group. To understand the role of noise and adaptation in such cases of bistable perception, we analyzed predictions from a model and found that contrast does indeed affect percept switches and durations as observed in the control group, in line with the hypothesis that lower stimulus contrast enhances internal noise effects. The combination of experimental and computational results presented here suggests a different motion coding mechanism in the amblyopic visual system, with relatively little effect of stimulus contrast on amblyopes' bistable motion perception.
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