Nature Communications (Apr 2020)

Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C

  • Aleksandra Bilska,
  • Monika Kusio-Kobiałka,
  • Paweł S. Krawczyk,
  • Olga Gewartowska,
  • Bartosz Tarkowski,
  • Kamil Kobyłecki,
  • Dominika Nowis,
  • Jakub Golab,
  • Jakub Gruchota,
  • Ewa Borsuk,
  • Andrzej Dziembowski,
  • Seweryn Mroczek

DOI
https://doi.org/10.1038/s41467-020-15835-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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Regulating polyadenylation is important for mRNA stability, which can in turn affect B cell maturation and humoral immune responses. Here the authors use Nanopore poly(A) sequencing to explore the importance of the cytoplasmic poly(A) polymerase TENT5C, particularly in the production of immunoglobulins.