Critical predictors of heart transplant necessity in children with advanced DCM

Abstract

Abstract Background Dilated Cardiomyopathy (DCM) frequently culminates in Heart Failure (HF), positioning it as the primary instigator of cardiac transplantation among pediatric patients. Nevertheless, the issue of cardiac transplantation in children demands a comprehensive and judicious strategy. The aim of this research was to ascertain the clinical attributes at the point of diagnosis that could potentially signal the requirement for transplantation in pediatric patients diagnosed with Dilated Cardiomyopathy (DCM). Methods In our study, we recognized 99 instances of pediatric cardiomyopathy accompanied by advanced heart failure (EF 0.05). A univariate logistic regression analysis demonstrated that NYHA score [aOR (95%CI) = 2.78 (1.06–7.27), p = 0.037], Ascites [aOR (95%CI) = 12.93 (2.45–68.22), p = 0.003], and Left ventricular noncompaction [aOR (95%CI) = 3.73 (1.01–13.86), p = 0.048] were all significantly correlated with the Transplantation group. Conclusions Pediatric dilated cardiomyopathy (DCM) presenting with indicators of progressive heart failure, including an elevated New York Heart Association (NYHA) classification, ascites, and left ventricular non-compaction, necessitates increased vigilance. It is advised that these cases be closely monitored, and early consideration should be given to heart transplantation as a potential therapeutic intervention.

Keywords

• Dilated cardiomyopathy (DCM)
• Children
• Heart failure (HF)
• Heart transplantation