Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain

Gui-Fang Duan; Yaxin Ye; Sha Xu; Wucheng Tao; Shiping Zhao; Tengchuan Jin; Roger A. Nicoll; Yun Stone Shi; Nengyin Sheng

doi:10.1038/s41467-018-07403-7

Nature Communications (Nov 2018)

Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain

Gui-Fang Duan,
Yaxin Ye,
Sha Xu,
Wucheng Tao,
Shiping Zhao,
Tengchuan Jin,
Roger A. Nicoll,
Yun Stone Shi,
Nengyin Sheng

Affiliations

Gui-Fang Duan: State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology, Nanjing Drum Tower Hospital, The Affliated Hospital of Nanjing University Medical School, and Minister of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University
Yaxin Ye: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
Sha Xu: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
Wucheng Tao: Department of Cellular and Molecular Pharmacology, University of California
Shiping Zhao: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
Tengchuan Jin: Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science and Technology of China
Roger A. Nicoll: Department of Cellular and Molecular Pharmacology, University of California
Yun Stone Shi: State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology, Nanjing Drum Tower Hospital, The Affliated Hospital of Nanjing University Medical School, and Minister of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University
Nengyin Sheng: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-018-07403-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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The two kainate receptors GluK1 and GluK2 show different surface expression and synaptic trafficking. Here authors engineer chimeric GluK1-GluK2 receptors and decipher a role how the signal peptide of GluK1 behaves as a ligand of GluK1 and modifies surface expression and trafficking.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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