Nature Communications (Aug 2018)

MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability

  • Dharmendra Dingar,
  • William B. Tu,
  • Diana Resetca,
  • Corey Lourenco,
  • Aaliya Tamachi,
  • Jason De Melo,
  • Kathleen E. Houlahan,
  • Manpreet Kalkat,
  • Pak-Kei Chan,
  • Paul C. Boutros,
  • Brian Raught,
  • Linda Z. Penn

DOI
https://doi.org/10.1038/s41467-018-05660-0
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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Deregulated MYC activity is oncogenic and is deregulated in a large fraction of human cancers. Here the authors find that protein phosphatase 1 and its regulatory subunit PNUTS controls MYC stability and its interaction with chromatin.