Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5−CD44+ cells

Dah-Jiun Fu; Lianghai Wang; Fouad K. Chouairi; Ian M. Rose; Danysh A. Abetov; Andrew D. Miller; Robert J. Yamulla; John C. Schimenti; Andrea Flesken-Nikitin; Alexander Yu. Nikitin

doi:10.1038/s41467-019-13847-2

Nature Communications (Jan 2020)

Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5−CD44+ cells

Dah-Jiun Fu,
Lianghai Wang,
Fouad K. Chouairi,
Ian M. Rose,
Danysh A. Abetov,
Andrew D. Miller,
Robert J. Yamulla,
John C. Schimenti,
Andrea Flesken-Nikitin,
Alexander Yu. Nikitin

Affiliations

Dah-Jiun Fu: Department of Biomedical Sciences and Cornell Stem Cell Program, Cornell University
Lianghai Wang: Department of Biomedical Sciences and Cornell Stem Cell Program, Cornell University
Fouad K. Chouairi: Department of Biomedical Sciences and Cornell Stem Cell Program, Cornell University
Ian M. Rose: Department of Biomedical Sciences and Cornell Stem Cell Program, Cornell University
Danysh A. Abetov: Department of Biomedical Sciences and Cornell Stem Cell Program, Cornell University
Andrew D. Miller: Department of Biomedical Sciences and Cornell Stem Cell Program, Cornell University
Robert J. Yamulla: Department of Biomedical Sciences and Cornell Stem Cell Program, Cornell University
John C. Schimenti: Department of Biomedical Sciences and Cornell Stem Cell Program, Cornell University
Andrea Flesken-Nikitin: Department of Biomedical Sciences and Cornell Stem Cell Program, Cornell University
Alexander Yu. Nikitin: Department of Biomedical Sciences and Cornell Stem Cell Program, Cornell University

DOI: https://doi.org/10.1038/s41467-019-13847-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Cancers arising from the gastric squamous-columnar junction have high incidence and are characterized by a poor prognosis. Here, the authors use genetic mouse models to show that loss of p53 and Rb1 expression results in preferential tumour development at the gastric squamous-columnar junction that contains a large pool of osteopontin responsive Lgr5-CD44+ cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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