eLife (Apr 2021)
Adiponectin preserves metabolic fitness during aging
- Na Li,
- Shangang Zhao,
- Zhuzhen Zhang,
- Yi Zhu,
- Christy M Gliniak,
- Lavanya Vishvanath,
- Yu A An,
- May-yun Wang,
- Yingfeng Deng,
- Qingzhang Zhu,
- Bo Shan,
- Amber Sherwood,
- Toshiharu Onodera,
- Orhan K Oz,
- Ruth Gordillo,
- Rana K Gupta,
- Ming Liu,
- Tamas L Horvath,
- Vishwa Deep Dixit,
- Philipp E Scherer
Affiliations
- Na Li
- ORCiD
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States; Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
- Shangang Zhao
- ORCiD
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States
- Zhuzhen Zhang
- ORCiD
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States
- Yi Zhu
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States
- Christy M Gliniak
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States
- Lavanya Vishvanath
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States
- Yu A An
- ORCiD
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States
- May-yun Wang
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States
- Yingfeng Deng
- ORCiD
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States
- Qingzhang Zhu
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States
- Bo Shan
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States
- Amber Sherwood
- Department of Radiology, University of Texas Southwestern Medical Center, Dallas, United States
- Toshiharu Onodera
- ORCiD
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States
- Orhan K Oz
- Department of Radiology, University of Texas Southwestern Medical Center, Dallas, United States
- Ruth Gordillo
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States
- Rana K Gupta
- ORCiD
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States
- Ming Liu
- ORCiD
- Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
- Tamas L Horvath
- ORCiD
- Department of Comparative Medicine and Immunobiology, Yale School of Medicine, New Haven, United States
- Vishwa Deep Dixit
- ORCiD
- Department of Comparative Medicine and Immunobiology, Yale School of Medicine, New Haven, United States; Yale Center for Research on Aging, Yale School of Medicine, New Haven, United States
- Philipp E Scherer
- ORCiD
- Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States; Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, United States
- DOI
- https://doi.org/10.7554/eLife.65108
- Journal volume & issue
-
Vol. 10
Abstract
Adiponectin is essential for the regulation of tissue substrate utilization and systemic insulin sensitivity. Clinical studies have suggested a positive association of circulating adiponectin with healthspan and lifespan. However, the direct effects of adiponectin on promoting healthspan and lifespan remain unexplored. Here, we are using an adiponectin null mouse and a transgenic adiponectin overexpression model. We directly assessed the effects of circulating adiponectin on the aging process and found that adiponectin null mice display exacerbated age-related glucose and lipid metabolism disorders. Moreover, adiponectin null mice have a significantly shortened lifespan on both chow and high-fat diet. In contrast, a transgenic mouse model with elevated circulating adiponectin levels has a dramatically improved systemic insulin sensitivity, reduced age-related tissue inflammation and fibrosis, and a prolonged healthspan and median lifespan. These results support a role of adiponectin as an essential regulator for healthspan and lifespan.
Keywords
