Nature Communications (May 2020)

Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure

  • Kun Zhao,
  • Yaowang Li,
  • Zhenying Liu,
  • Houfang Long,
  • Chunyu Zhao,
  • Feng Luo,
  • Yunpeng Sun,
  • Youqi Tao,
  • Xiao-dong Su,
  • Dan Li,
  • Xueming Li,
  • Cong Liu

DOI
https://doi.org/10.1038/s41467-020-16386-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 9

Abstract

Read online

The E46K α-synuclein mutation causes familial Parkinson’s disease. Here, the authors present the cryo-EM structure of N-terminally acetylated E46K α-synuclein fibrils and find that it is distinct from other known α-synuclein fibril structures.