Nature Communications (May 2019)

Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions

  • Laura Pirovano,
  • Simone Culurgioni,
  • Manuel Carminati,
  • Andrea Alfieri,
  • Silvia Monzani,
  • Valentina Cecatiello,
  • Chiara Gaddoni,
  • Francesca Rizzelli,
  • James Foadi,
  • Sebastiano Pasqualato,
  • Marina Mapelli

DOI
https://doi.org/10.1038/s41467-019-09999-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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LGN and NuMA link epithelial polarity sites with astral microtubules and associate with dynein, but the architecture of such cortical force-generating complexes is unknown. Here, the authors report the crystal structure of NuMA:LGN hetero-hexamers, and unveil their role in promoting the assembly of active cortical dynein/dynactin motors.