Nature Communications (Sep 2019)

BORDER proteins protect expression of neighboring genes by promoting 3′ Pol II pausing in plants

  • Xuhong Yu,
  • Pascal G. P. Martin,
  • Scott D. Michaels

DOI
https://doi.org/10.1038/s41467-019-12328-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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In plants, 3′ Pol II pausing helps prevent transcriptional interference. Here the authors provide evidence that BORDER proteins are enriched in intergenic regions and inhibit transcriptional interference between closely spaced genes by preventing RNA polymerase from intruding into the promoters of nearby downstream genes.