Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp2)−H bonds

Abstract

Directed activation of C–H bonds usually occurs through 5-membered metallacycles, which poses limitations of regiochemistry. Herein, the authors use a phosphine oxide-ligated Ni−Al bimetallic catalyst to enable β-C−H bond-involved hydroarylations of alkynes via a rare 7-membered nickelacycle.