Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3

Albert Castellví; Raquel Pequerul; Vito Barracco; Judith Juanhuix; Xavier Parés; Jaume Farrés

doi:10.1038/s42003-022-03311-1

Communications Biology (Apr 2022)

Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3

Albert Castellví,
Raquel Pequerul,
Vito Barracco,
Judith Juanhuix,
Xavier Parés,
Jaume Farrés

Affiliations

Albert Castellví: Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona
Raquel Pequerul: Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona
Vito Barracco: Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona
Judith Juanhuix: Alba Synchrotron
Xavier Parés: Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona
Jaume Farrés: Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona

DOI: https://doi.org/10.1038/s42003-022-03311-1
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 12

Abstract

Read online

Three X-ray structures are presented of human aldehyde dehydrogenase family 1 member A3 (ALDH1A3), a potential cancer stem cell biomarker (alone, with NAD+ and with ATP) and structure determination performed using molecular replacement.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal