DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus

Pedram Shafiei-Jahani; Benjamin P. Hurrell; Lauriane Galle-Treger; Doumet Georges Helou; Emily Howard; Jacob Painter; Richard Lo; Gavin Lewis; Pejman Soroosh; Omid Akbari

doi:10.1038/s41467-020-18601-7

Nature Communications (Sep 2020)

DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus

Pedram Shafiei-Jahani,
Benjamin P. Hurrell,
Lauriane Galle-Treger,
Doumet Georges Helou,
Emily Howard,
Jacob Painter,
Richard Lo,
Gavin Lewis,
Pejman Soroosh,
Omid Akbari

Affiliations

Pedram Shafiei-Jahani: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Benjamin P. Hurrell: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Lauriane Galle-Treger: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Doumet Georges Helou: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Emily Howard: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Jacob Painter: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Richard Lo: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Gavin Lewis: Janssen Research and Development
Pejman Soroosh: Janssen Research and Development
Omid Akbari: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California

DOI: https://doi.org/10.1038/s41467-020-18601-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Group 2 innate lymphoid cells (ILC2s) are immune cells present in adipose tissue that contribute to metabolic homeostasis. Here the authors show that Death Receptor 3 (DR3) engagement on ILC2s ameliorates glucose tolerance, protects against insulin-resistance onset and reverses established insulin-resistance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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