A binding-enhanced but enzymatic activity-eliminated human ACE2 efficiently neutralizes SARS-CoV-2 variants

• Anqi Zheng,
• Lili Wu,
• Renyi Ma,
• Pu Han,
• Baoying Huang,
• Chengpeng Qiao,
• Qihui Wang,
• Wenjie Tan,
• George F. Gao,
• Pengcheng Han

Affiliations

Anqi Zheng

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences

Lili Wu

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences

Renyi Ma

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences

Pu Han

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences

Baoying Huang

National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC)

Chengpeng Qiao

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences

Qihui Wang

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences

Wenjie Tan

National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC)

George F. Gao

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences

Pengcheng Han

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences