Inverse Correlation Between Grip Strength and Serum Phosphorus: A Retrospective Observational Study in Japanese Elderly with Poorly Controlled Type 2 Diabetes
Sho Tanaka,
Masahiro Takubo,
Genta Kohno,
Masaru Kushimoto,
Jin Ikeda,
Katsuhiko Ogawa,
Yutaka Suzuki,
Masanori Abe,
Hisamitsu Ishihara,
Midori Fujishiro
Affiliations
Sho Tanaka
Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo 173-8610, Japan
Masahiro Takubo
Department of Internal Medicine, Nihon University Hospital, Tokyo 101-8309, Japan
Genta Kohno
Division of Diabetes and Metabolic Diseases, Department of Internal Medicine, Nihon University School of Medicine, Tokyo 173-8610, Japan
Masaru Kushimoto
Department of Internal Medicine, Nihon University Hospital, Tokyo 101-8309, Japan
Jin Ikeda
Department of Internal Medicine, Nihon University Hospital, Tokyo 101-8309, Japan
Katsuhiko Ogawa
Department of Internal Medicine, Nihon University Hospital, Tokyo 101-8309, Japan
Yutaka Suzuki
Department of Internal Medicine, Nihon University Hospital, Tokyo 101-8309, Japan
Masanori Abe
Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo 173-8610, Japan
Hisamitsu Ishihara
Division of Diabetes and Metabolic Diseases, Department of Internal Medicine, Nihon University School of Medicine, Tokyo 173-8610, Japan
Midori Fujishiro
Department of Internal Medicine, Nihon University Hospital, Tokyo 101-8309, Japan
The aim of this study was to investigate factors associated with sarcopenia among elderly patients with poorly controlled diabetes mellitus (DM). We retrospectively analyzed 41 patients with type 2 DM, aged ≥65 years who required diabetes education hospitalization. Patients were classified into two groups according to the presence or absence of a weakened hand grip, and clinical characteristics were compared. Patients with a weakened hand grip (n = 21) scored worse on a mini-mental state examination (24.3 vs. 26.5, p = 0.04), showed a higher prevalence of diabetic peripheral neuropathy (76% vs. 40%, p = 0.03), and had a higher serum phosphorus concentration (3.8 vs. 3.3 mg/dL, p n = 20). The serum phosphorus concentration was inversely correlated to hand grip strength (r = −0.501, p < 0.001) among the total of 41 patients. This inverse association was also confirmed after adjusting the effects of estimated glomerular filtration rate, age, and glycated hemoglobin. Thus, cognitive impairment, diabetic peripheral neuropathy, and high serum phosphorus concentrations are associated with hand grip weakness in elderly patients with type 2 DM.
