Immunohistochemical investigation of neuroendocrine component in prostate adenocarcinoma

Abstract

A purpose of current research was to investigate the neuroendocrine component of prostate adenocarcinoma. The immunohistochemical investigation with using markers of neuroendocine differentiation – chromogranin A and neuronspecific enolase was performed. The neuroendocrine differentiation in light-cell adenocarcinoma is more expressive comparing with poorly dark-cell adenocarcinoma, and the neuroendocrine differentiation in moderately differentiated adenocarcinoma is more expressive comparing with poorly differentiated adenocarcinoma.

Keywords

• prostate adenocarcinoma
• neuroendocrine differentiation
• immunohistochemical investigation
• chromogranin A
• neuron-specific enolase