Frontiers in Pharmacology (Apr 2022)

Shenling Baizhu Powder Alleviates TNBS-Induced Colitis in Rats by Improving Intestinal Epithelial Permeability and Inhibiting Inflammation Through the TLR5/MyD88/NF-κB Pathway

  • Kehan Rao,
  • Shumin Qin,
  • Shumin Qin,
  • Shumin Qin,
  • Shumin Qin,
  • Shumin Qin,
  • Yuanming Yang,
  • Kai Zhan,
  • Haomeng Wu,
  • Haomeng Wu,
  • Haomeng Wu,
  • Haomeng Wu,
  • Haomeng Wu,
  • Huan Zheng,
  • Huan Zheng,
  • Huan Zheng,
  • Huan Zheng,
  • Huan Zheng,
  • Shaogang Huang,
  • Shaogang Huang,
  • Shaogang Huang,
  • Shaogang Huang,
  • Shaogang Huang,
  • Shaogang Huang

DOI
https://doi.org/10.3389/fphar.2022.883918
Journal volume & issue
Vol. 13

Abstract

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Aim of the study: To evaluate the protective effect and mechanism of shenling baizhu powder (SBP) on TNBS-induced colitis.Methods: Rats were given TNBS to establish the model of colitis and subsequently treated with different doses of SBP or mesalamine (MES). In addition, the expression of the TLR5/MyD88/NF-κB signaling pathway and critical targets of the intestinal mucosal barrier was detected by immunochemical analysis techniques.Results: SBP significantly ameliorated the symptoms of TNBS-induced colitis in rats and reduced the secretion of pro-inflammatory cytokines. SBP could effectively strengthen epithelial barrier integrity in TNBS-induced colitis by increasing the secretion of mucin and tight junction and inhibiting apoptosis. Furthermore, we identified the crucial role of the TLR5/MyD88/NF-κB signaling pathway in exerting the therapeutic effect of SBP.Conclusion: The results of our study suggest that SBP has therapeutic effects on TNBS-induced colitis and potential value in treating and maintaining remission of colitis.

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