Revista da Sociedade Brasileira de Medicina Tropical ()

Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits

  • Flávio Augusto de Souza Oliveira,
  • Guilherme Matos Passarini,
  • Daniel Sol Sol de Medeiros,
  • Ana Paula de Azevedo Santos,
  • Saara Neri Fialho,
  • Aurileya de Jesus Gouveia,
  • Marcinete Latorre,
  • Elci Marlei Freitag,
  • Patrícia Soares de Maria de Medeiros,
  • Carolina Bioni Garcia Teles,
  • Valdir Alves Facundo

DOI
https://doi.org/10.1590/0037-8682-0309-2017
Journal volume & issue
Vol. 51, no. 3
pp. 382 – 386

Abstract

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Abstract INTRODUCTION This study assessed the activity of compounds from Piper tuberculatum against Plasmodium falciparum and Leishmania guyanensis. METHODS The effects of compounds from P. tuberculatum fruits on P. falciparum and L. guyanensis promastigote growth in vitro were determined. Hemolytic action and cytotoxicity in HepG2 and J774 cells were measured. RESULTS Three compounds showed strong antiplasmodial activity and one compound showed strong antileishmanial activity. Two compounds were non-toxic to HepG2 cells and all were toxic to J774 cells. The compounds showed no hemolytic activity. CONCLUSIONS The tested compounds from P. tuberculatum exhibited antiparasitic and cytotoxic effects.

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