eLife (Mar 2021)

Genomic and healthcare dynamics of nosocomial SARS-CoV-2 transmission

  • Jamie M Ellingford,
  • Ryan George,
  • John H McDermott,
  • Shazaad Ahmad,
  • Jonathan J Edgerley,
  • David Gokhale,
  • William G Newman,
  • Stephen Ball,
  • Nicholas Machin,
  • Graeme CM Black

DOI
https://doi.org/10.7554/eLife.65453
Journal volume & issue
Vol. 10

Abstract

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Understanding the effectiveness of infection control methods in reducing and preventing SARS-CoV-2 transmission in healthcare settings is of high importance. We sequenced SARS-CoV-2 genomes for patients and healthcare workers (HCWs) across multiple geographically distinct UK hospitals, obtaining 173 high-quality SARS-CoV-2 genomes. We integrated patient movement and staff location data into the analysis of viral genome data to understand spatial and temporal dynamics of SARS-CoV-2 transmission. We identified eight patient contact clusters (PCC) with significantly increased similarity in genomic variants compared to non-clustered samples. Incorporation of HCW location further increased the number of individuals within PCCs and identified additional links in SARS-CoV-2 transmission pathways. Patients within PCCs carried viruses more genetically identical to HCWs in the same ward location. SARS-CoV-2 genome sequencing integrated with patient and HCW movement data increases identification of outbreak clusters. This dynamic approach can support infection control management strategies within the healthcare setting.

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