Antidiabetic effect of Borassus flabellifer L. extracts on streptozotocin-induced diabetic rats

Abstract

Background: Around the world, the number of people with diabetes is rising at an alarming rate, and experts have been using ancient drugs that are mostly made from plants as treatments.This study aimed to see if Borassus flabellifer L. palm sprout ethanolic extracts could help treat diabetes in rats made diabetic by streptozotocin (STZ). Methods: STZ (45 mg/kg bw) was injected once into the peritoneum of male albino Wistar rats. This caused them to get diabetes. For 60 days, intragastric intubation was used to give diabetic rats B. flabellifer palm sprout ethanolic extracts (400 mg/kg bw) and glibenclamide (1 mg/kg bw). Results: As a result, the rats lost a lot of weight, their blood sugar and glycosylated hemoglobin levels went up, and their total hemoglobin (Hb) levels went down. Furthermore, glucose-6-phosphatase and fructose-1,6-bis phosphatase were higher in rats made diabetic by STZ, while hexokinase and glycogen levels were lower. When diabetic rats were given ethanolic extracts of B. flabellifer palm sprouts and glibenclamide, their blood glucose and glycosylated Hb levels went down very well, and their Hb levels went up. Changes in how enzymes that break down carbohydrates and liver glycogen work were greatly improved. Conclusion: The results of the ethanolic extracts of B. flabellifer palm sprouts were similar to those of the standard drug glibenclamide. The results of this study back up the traditional use of plant extracts to treat diabetes.

Keywords

• borassus fabellifier l
• carbohydrate metabolizing enzyme
• in vivo antidiabetic activity
• liver glycogen