Research progress on the role of kallikrein 8 in neurological diseases

Abstract

Kallikrein 8(KLK8) is closely related to the central nervous system and is involved in the pathological processes of many neurological diseases by altering inter-synaptic adhesion relationships and extracellular matrix molecules thereby modifying synaptic morphology and regulating synaptic plasticity. In this paper, we review the role and pathogenesis of KLK8 in neurological disorders such as dysthymic disorders, Alzheimer's disease, epilepsy, and multiple sclerosis with respect to its physiological properties. It is expected to provide a theoretical basis for the diagnosis and prognosis of neurological diseases and provide directions for the research of such diseases.

Keywords

• kallikrein 8|synaptic plasticity|dysthymic disorders|alzheimer's disease