Metabolic Control of γδ T Cell Function

Abstract

Abstract. Metabolic change is associated with cell activities, such as signal transduction, cell differentiation, and cell cycle. In the pathogenesis of autoimmune diseases, abnormal activation of T cells is often accompanied by changes in their metabolism. Conversely, the changes of metabolites can also regulate the proliferation, differentiation, and function of T cells. As a bridge between innate and adaptive immune responses, γδ T cells have unique biological characteristics and functions. However, the immunometabolic mechanism of γδ T cells has been a novel field for research in recent years. In this review, we summarize the influence of metabolic pathways and nutrients on γδ T cell function, and metabolic features of γδ T cell subsets, which may provide new insights in interventions targeting γδ T cells in disease control.