The Effect of Gelfoam Impregnated With Botulinum Toxin on Allergic Rhinitis Symptoms

Vahid Zand; Mohammadhossein Baradaranfar; Mohammadhossein Dadgarnia; Mojtaba Meybodian; Sedighe Vaziribozorg; Mohammad Mandegari; Nasrin Behniafard; Amrollah Dehghani

doi:10.22038/ijorl.2018.31884.2046

Iranian Journal of Otorhinolaryngology (Jul 2019)

The Effect of Gelfoam Impregnated With Botulinum Toxin on Allergic Rhinitis Symptoms

Vahid Zand,
Mohammadhossein Baradaranfar,
Mohammadhossein Dadgarnia,
Mojtaba Meybodian,
Sedighe Vaziribozorg,
Mohammad Mandegari,
Nasrin Behniafard,
Amrollah Dehghani

Affiliations

Vahid Zand: Department of Otolaryngology- Head and Neck Surgery, Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohammadhossein Baradaranfar: Department of Otolaryngology- Head and Neck Surgery, Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohammadhossein Dadgarnia: Department of Otolaryngology- Head and Neck Surgery, Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mojtaba Meybodian: Department of Otolaryngology- Head and Neck Surgery, Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Sedighe Vaziribozorg: Department of Otolaryngology- Head and Neck Surgery, Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohammad Mandegari: Department of Otolaryngology- Head and Neck Surgery, Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Nasrin Behniafard: Department of Allergy and Clinical Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Amrollah Dehghani: Department of Otolaryngology- Head and Neck Surgery, Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

DOI: https://doi.org/10.22038/ijorl.2018.31884.2046
Journal volume & issue: Vol. 31, no. 4
pp. 203 – 208

Abstract

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Introduction: This study evaluated the effect of gelfoam impregnated with botulinum toxin on the symptoms induced by allergic rhinitis. Materials and Methods: In total, 30 patients with allergic rhinitis who did not respond to common therapies were included in this clinical trial study. All patients were treated with intranasal gelfoam impregnated with botulinum toxin type a (40 unit in each side) placed in the middle meatus of each nostril. The main symptoms of allergic rhinitis were scored from zero to three by the patients. Symptoms recorded and compared before and two months after the treatment. Result: The mean age of patients was 31.03±6.9 years. The mean score for sneezing was 2.23 before the treatment which significantly decreased to 1.06 after the treatment (P Conclusion: According to the results, treatment with gelfoam impregnated with botulinum toxin is an effective and safe method in patients who have not responded to common therapies for allergic rhinitis. Accordingly, it is recommended to relieve symptoms in patients with seasonal allergic rhinitis in order to maintain the effectiveness of this treatment at least 8 weeks.

Published in Iranian Journal of Otorhinolaryngology

ISSN: 2251-7251 (Print); 2251-726X (Online)
Publisher: Mashhad University of Medical Sciences
Country of publisher: Iran, Islamic Republic of
LCC subjects: Medicine: Otorhinolaryngology
Website: http://ijorl.mums.ac.ir/

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