Nature Communications (Jul 2022)
T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice
- Venetia Bazioti,
- Anouk M. La Rose,
- Sjors Maassen,
- Frans Bianchi,
- Rinse de Boer,
- Benedek Halmos,
- Deepti Dabral,
- Emma Guilbaud,
- Arthur Flohr-Svendsen,
- Anouk G. Groenen,
- Alejandro Marmolejo-Garza,
- Mirjam H. Koster,
- Niels J. Kloosterhuis,
- Rick Havinga,
- Alle T. Pranger,
- Miriam Langelaar-Makkinje,
- Alain de Bruin,
- Bart van de Sluis,
- Alison B. Kohan,
- Laurent Yvan-Charvet,
- Geert van den Bogaart,
- Marit Westerterp
Affiliations
- Venetia Bazioti
- Department of Pediatrics, University Medical Center Groningen, University of Groningen
- Anouk M. La Rose
- Department of Pediatrics, University Medical Center Groningen, University of Groningen
- Sjors Maassen
- Department of Molecular Immunology and Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen
- Frans Bianchi
- Department of Molecular Immunology and Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen
- Rinse de Boer
- Department of Molecular Immunology and Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen
- Benedek Halmos
- Department of Pediatrics, University Medical Center Groningen, University of Groningen
- Deepti Dabral
- Department of Molecular Immunology and Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen
- Emma Guilbaud
- Institut National de la Santé et de la Recherche Médicale (INSERM) U1065, Université Côte d’Azur, Centre Méditerranéen de Médecine Moléculaire (C3M), Atip-Avenir, Fédération Hospitalo-Universitaire (FHU) Oncoage
- Arthur Flohr-Svendsen
- European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen
- Anouk G. Groenen
- Department of Pediatrics, University Medical Center Groningen, University of Groningen
- Alejandro Marmolejo-Garza
- Department of Pediatrics, University Medical Center Groningen, University of Groningen
- Mirjam H. Koster
- Department of Pediatrics, University Medical Center Groningen, University of Groningen
- Niels J. Kloosterhuis
- Department of Pediatrics, University Medical Center Groningen, University of Groningen
- Rick Havinga
- Department of Pediatrics, University Medical Center Groningen, University of Groningen
- Alle T. Pranger
- Laboratory of Medicine, University Medical Center Groningen, University of Groningen
- Miriam Langelaar-Makkinje
- Department of Pediatrics, University Medical Center Groningen, University of Groningen
- Alain de Bruin
- Department of Pediatrics, University Medical Center Groningen, University of Groningen
- Bart van de Sluis
- Department of Pediatrics, University Medical Center Groningen, University of Groningen
- Alison B. Kohan
- Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh
- Laurent Yvan-Charvet
- Institut National de la Santé et de la Recherche Médicale (INSERM) U1065, Université Côte d’Azur, Centre Méditerranéen de Médecine Moléculaire (C3M), Atip-Avenir, Fédération Hospitalo-Universitaire (FHU) Oncoage
- Geert van den Bogaart
- Department of Molecular Immunology and Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen
- Marit Westerterp
- Department of Pediatrics, University Medical Center Groningen, University of Groningen
- DOI
- https://doi.org/10.1038/s41467-022-31135-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 23
Abstract
Cholesterol efflux is mediated by specific transporters in T cells. Here the authors show that when the ABCA1/ABCG1 cholesterol transporters are absent, peripheral T cell numbers are reduced but activation increased with a premature aging phenotype of T cell senescence and apoptosis in middle aged Ldlr −/− mice.
