Zhongguo quanke yixue (May 2022)

Associations of P-selectin and Thromboxane B2 Expression Levels with Efficacy and Prognosis in Patients with Ischemic Stroke Affecting Different Parts of the Brain

  • Cancan MENG, Yan CHENG, Liyan JIAO, Zhiwei ZHANG, Weigang LIU, Zhitang YANG

DOI
https://doi.org/10.12114/j.issn.1007-9572.2022.0020
Journal volume & issue
Vol. 25, no. 14
pp. 1736 – 1740

Abstract

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Background Epidemiological investigations have demonstrated that the number of stroke cases is increasing recently, and stroke has become a leading cause of death. Patients affected by ischemic stroke, the most prevalent type of stroke, may have different therapeutic efficacies and prognosis if the affected parts are different, and platelet activation may play a vital role in the development of ischemic stroke. Objective To investigate the associations of P-selectin (CD62P) and thromboxane B2 (TXB2) expression levels with efficacy and prognosis in patients with ischemic stroke affecting different parts of the brain. Methods Participants were recruited from Department of Neurology, Affiliated Hospital of Hebei Engineering University from October 2019 to June 2021, including 44 neurology patients with ischemic stroke (23 with anterior circulation stroke and 21 with posterior circulation stroke) , and 28 healthy physical examinees. Demographics and routine blood test indicators of all participants were collected. The National Institutes of Health Stroke Scale (NIHSS) was used to assess the degree of neurological impairment, and ELISA was used to detect the levels of CD62P and TXB2 of ischemic stroke patients at baseline, on the 7th and 30th days of treatment, respectively. The Modified Rankin Scale (mRS) was used to assess the prognosis of ischemic stroke patients on the 30th day of treatment. Results Before treatment, both anterior and posterior circulation stroke patients had higher mean levels of CD62P and TXB2 than did the physical examinees (P<0.05) . On the 7th and 30th days of treatment, the mean NIHSS score, CD62P and TXB2 levels in posterior circulation stroke patients were higher than those of anterior circulation stroke patients (P<0.05) . On the 30th day of treatment, the mean mRS score in anterior circulation stroke patients was lower than that of posterior circulation stroke patients (P=0.001) . Conclusion Posterior circulation stroke patients had higher mean levels of CD62P and TXB2 and poorer efficacy and prognosis than did anterior circulation stroke patients, suggesting that the level of platelet activation may play a role in the treatment and prognosis of ischemic stroke patients.

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