Maternal and Neonatal Outcomes of SARS-CoV-2 Infection in a Cohort of Pregnant Women with Comorbid Disorders
Maria de Lourdes Benamor Teixeira,
Orlando da Costa Ferreira Júnior,
Esaú João,
Trevon Fuller,
Juliana Silva Esteves,
Wallace Mendes-Silva,
Carolina Carvalho Mocarzel,
Richard Araújo Maia,
Lídia Theodoro Boullosa,
Cássia Cristina Alves Gonçalves,
Patrícia Pontes Frankel,
Maria Isabel Fragoso da Silveira Gouvêa
Affiliations
Maria de Lourdes Benamor Teixeira
Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rua Sacadura Cabral, 178, Anexo IV 4° Andar, Rio de Janeiro 20221-161, RJ, Brazil
Orlando da Costa Ferreira Júnior
Laboratório de Biologia Molecular, Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373—Sala A1-050—Cidade Universitária da Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil
Esaú João
Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rua Sacadura Cabral, 178, Anexo IV 4° Andar, Rio de Janeiro 20221-161, RJ, Brazil
Trevon Fuller
Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rua Sacadura Cabral, 178, Anexo IV 4° Andar, Rio de Janeiro 20221-161, RJ, Brazil
Juliana Silva Esteves
Maternal Fetal Department and Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rua Sacadura Cabral, 178, Rio de Janeiro 20221-161, RJ, Brazil
Wallace Mendes-Silva
Maternal Fetal Department and Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rua Sacadura Cabral, 178, Rio de Janeiro 20221-161, RJ, Brazil
Carolina Carvalho Mocarzel
Maternal Fetal Department and Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rua Sacadura Cabral, 178, Rio de Janeiro 20221-161, RJ, Brazil
Richard Araújo Maia
Laboratório de Biologia Molecular, Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373—Sala A1-050—Cidade Universitária da Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil
Lídia Theodoro Boullosa
Laboratório de Biologia Molecular, Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373—Sala A1-050—Cidade Universitária da Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil
Cássia Cristina Alves Gonçalves
Laboratório de Biologia Molecular, Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373—Sala A1-050—Cidade Universitária da Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil
Patrícia Pontes Frankel
Maternal Fetal Department and Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rua Sacadura Cabral, 178, Rio de Janeiro 20221-161, RJ, Brazil
Maria Isabel Fragoso da Silveira Gouvêa
Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rua Sacadura Cabral, 178, Anexo IV 4° Andar, Rio de Janeiro 20221-161, RJ, Brazil
There are some reports and case series addressing Coronavirus Disease 2019 (COVID-19) infections during pregnancy in upper income countries, but there are few data on pregnant women with comorbid conditions in low and middle income Countries. This study evaluated the proportion and the maternal and neonatal outcomes associated with SARS-CoV-2 infection among pregnant women with comorbidities. Participants were recruited consecutively in order of admission to a maternity for pregnant women with comorbidities. Sociodemographic, clinical, and laboratory data were prospectively collected during hospitalization. Pregnant women were screened at entry: nasopharyngeal swabs were tested by RT-PCR; serum samples were tested for IgG antibodies against spike protein by ELISA. From April to June 2020, 115 eligible women were included in the study. The proportion of SARS-CoV-2 infection was 28.7%. The rate of obesity was 60.9%, vascular hypertension 40.0%, and HIV 21.7%. The most common clinical presentations were ageusia (21.2%), anosmia (18.2%), and fever (18.2%). Prematurity was higher among mothers who had a SARS-CoV-2 infection based on RT-PCR. There were two cases of fetal demise. We found a high proportion of COVID-19 among pregnant women with comorbidities. This underscores the importance of antenatal care during the pandemic to implement universal SARS-CoV-2 screening, precautionary measures, and the rollout of vaccination programs for pregnant women.
