Histopathological changes in the kidney tissues of white Swiss mice (Mus musculus L.) exposed to alpha-cypermethrin

Abstract

Introduction: Alpha-cypermethrin is a pyrethroid insecticide. Chronic exposure to alpha-cypermethrin is mainly due to the usage in household pest control or through drinking water and contaminated fruits and vegetables. The kidneys are considered as an essential organ in human and animal bodies. One of the causes of nephrotoxicity is exposure to environmental pollutants. Objectives: The present study was designed to investigate the deleterious effects of alpha-cypermethrin when administered in two doses in the kidney tissues of mice. Patients and Methods: The kidneys of treated and control mice were removed and fixed in 10% neutral buffered formalin. Subsequently, the specimens were passed by a series of concentrations of ethyl alcohol and embedded in paraffin and finally stained with hematoxylin and eosin. Results: Treated mice groups are being investigated with several histopathological changes in their kidney tissues even at low-concentration of dose. These changes varied in males and female laboratory mice. These effects included bleeding, congestion, edema, aggregation of fat cells in various sizes and inflammation and death renal cells. Additionally, vacuolization of cytoplasm, necrosis, loss of glomeruli, shrinkage of tubular cell nuclei, necrosis of some tubular cells, enlargement or death of these cells, congestion and dilation Bowman’s space, hemorrhage and hyperplasia of cells were also existed. Conclusion: This research confirmed that alpha-cypermethrin causes severe deterioration in kidney tissues of Swiss albino mice.

Keywords

• alpha-cypermethrin
• swiss mice
• kidney
• histopathology
• pesticides