Evolutionary instability of CUG-Leu in the genetic code of budding yeasts

Tadeusz Krassowski; Aisling Y. Coughlan; Xing-Xing Shen; Xiaofan Zhou; Jacek Kominek; Dana A. Opulente; Robert Riley; Igor V. Grigoriev; Nikunj Maheshwari; Denis C. Shields; Cletus P. Kurtzman; Chris Todd Hittinger; Antonis Rokas; Kenneth H. Wolfe

doi:10.1038/s41467-018-04374-7

Nature Communications (May 2018)

Evolutionary instability of CUG-Leu in the genetic code of budding yeasts

Tadeusz Krassowski,
Aisling Y. Coughlan,
Xing-Xing Shen,
Xiaofan Zhou,
Jacek Kominek,
Dana A. Opulente,
Robert Riley,
Igor V. Grigoriev,
Nikunj Maheshwari,
Denis C. Shields,
Cletus P. Kurtzman,
Chris Todd Hittinger,
Antonis Rokas,
Kenneth H. Wolfe

Affiliations

Tadeusz Krassowski: Conway Institute and School of Medicine, University College Dublin
Aisling Y. Coughlan: Conway Institute and School of Medicine, University College Dublin
Xing-Xing Shen: Department of Biological Sciences, Vanderbilt University
Xiaofan Zhou: Department of Biological Sciences, Vanderbilt University
Jacek Kominek: Laboratory of Genetics, Genome Center of Wisconsin, J.F. Crow Institute for the Study of Evolution, Wisconsin Energy Institute, University of Wisconsin-Madison
Dana A. Opulente: Laboratory of Genetics, Genome Center of Wisconsin, J.F. Crow Institute for the Study of Evolution, Wisconsin Energy Institute, University of Wisconsin-Madison
Robert Riley: United States Department of Energy Joint Genome Institute
Igor V. Grigoriev: United States Department of Energy Joint Genome Institute
Nikunj Maheshwari: Conway Institute and School of Medicine, University College Dublin
Denis C. Shields: Conway Institute and School of Medicine, University College Dublin
Cletus P. Kurtzman: U.S. Department of Agriculture, Mycotoxin Prevention and Applied Microbiology Research Unit, National Center for Agricultural Utilization Research, Agricultural Research Service
Chris Todd Hittinger: Laboratory of Genetics, Genome Center of Wisconsin, J.F. Crow Institute for the Study of Evolution, Wisconsin Energy Institute, University of Wisconsin-Madison
Antonis Rokas: Department of Biological Sciences, Vanderbilt University
Kenneth H. Wolfe: Conway Institute and School of Medicine, University College Dublin

DOI: https://doi.org/10.1038/s41467-018-04374-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 8

Abstract

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The genetic code for amino acids is nearly universal, and among eukaryotic nuclear genomes the only known reassignments are of codon CUG in yeasts. Here, the authors identify a third independent CUG transition in budding yeasts that is still ongoing with alternative tRNAs present in the genome.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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