Tracking the evolution of esophageal squamous cell carcinoma under dynamic immune selection by multi-omics sequencing

Abstract

It is essential to understand heterogeneity and evolution at different omics levels in oesophageal squamous cell carcinoma (ESCC). Here, the authors use multi-omics to analyse heterogeneity and evolution in ESCC patient samples, and characterise the levels of immune infiltration as well as selective pressure from the tumour microenvironment.