Molecules (Aug 2022)

The Efficacy of Aprotinin Combinations with Selected Antiviral Drugs in Mouse Models of Influenza Pneumonia and Coronavirus Infection Caused by SARS-CoV-2

  • Andrey A. Ivashchenko,
  • Bogdan A. Zagribelnyy,
  • Yan A. Ivanenkov,
  • Ilya A. Ivashchenko,
  • Ruben N. Karapetian,
  • Dmitry V. Kravchenko,
  • Nikolay P. Savchuk,
  • Elena V. Yakubova,
  • Alexandre V. Ivachtchenko

DOI
https://doi.org/10.3390/molecules27154975
Journal volume & issue
Vol. 27, no. 15
p. 4975

Abstract

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The efficacy of aprotinin combinations with selected antiviral-drugs treatment of influenza virus and coronavirus (SARS-CoV-2) infection was studied in mice models of influenza pneumonia and COVID-19. The high efficacy of the combinations in reducing virus titer in lungs and body weight loss and in increasing the survival rate were demonstrated. This preclinical study can be considered a confirmatory step before introducing the combinations into clinical assessment.

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