Prognostic value of mean platelet volume to plateletcrit ratio in patients with osteosarcoma

Abstract

Bo Gou, Hong Cao, Xinghua Cheng, Wei Shang, Mingqing Xu, Wei Qian Department of Orthopedics, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China Objective: The objective of this study was to investigate the prognostic value of preoperative mean platelet volume to plateletcrit (MPV/PCT) ratio in patients with osteosarcoma. Materials and methods: The retrospective study included 188 consecutive osteosarcoma patients who experienced neoadjuvant chemotherapy and surgical resection of tumor. The relationships between MPV/PCT and clinicopathological characteristics were analyzed. The Kaplan–Meier analysis and Cox regression proportional hazard model were applied to assess the prognostic value of MPV/PCT ratio.Results: MPV/PCT ratio was found to be significantly associated with platelet count, platelet distribution width, and PCT (all P<0.001). Kaplan–Meier analysis showed that high MPV/PCT ratio (≥43.58) was associated with a prolonged disease-free survival (DFS, P=0.035). The multivariate Cox revealed that only good chemotherapy response was an independent predictor of better DFS in the overall population. However, the stratification analysis showed that a high MPV/PCT ratio (≥43.58) was indicated as an independent prognostic factor for a favorable DFS (HR =0.137, 95%CI =0.029–0.644, P=0.012) in the male osteosarcoma patients but not in female patients.Conclusion: The high preoperative MPV/PCT ratio may serve as an independent prognostic factor for a favorable prognosis in male osteosarcoma patients. Further studies are needed to confirm the findings.Keywords: osteosarcoma, MPV/PCT, prognosis, platelet indices

Keywords

• osteosarcoma
• MPV/PCT
• prognosis
• platelet indices