Indian Journal of Dermatology (Jan 2005)

Composite lymphoma: Mycosis fungoides with hodgkin′s lymphoma

  • Mehta Jalpa,
  • Phiske Meghana,
  • Dhurat R,
  • Jerajani H,
  • Kapoor Rinky,
  • Randhive Nilima

Journal volume & issue
Vol. 50, no. 4
pp. 227 – 230

Abstract

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Mycosis fungoides (MF) is a malignant lymphoma, primarily of the skin and is characterized by infiltration of the skin by atypical T-cells which have a tendency for epidermotropism. Hodgkins disease (HD) is considered to be a malignant lymphoma affecting predominantly the lymph nodes and characterized by presence of Reed- Sternberg cells on histopathology, though, the exact origin of the Reed Sternberg cell and the nature of the malignant cell is not known yet. Few cases of association of mycosis fungoides with Hodgkin′s lymphoma have been reported in the literature. It was reported in the past that when mycosis fungoides spreads to the lymph nodes and other viscera it frequently gets transformed into a more common lymphoma like Hodgkin′s lymphoma. However it has now been proved that the two malignancies are distinct and that such patients probably have a tumour diathesis.

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