Nature Communications (May 2021)

Cryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals features of arthritogenic alphaviruses

  • Helder V. Ribeiro-Filho,
  • Lais D. Coimbra,
  • Alexandre Cassago,
  • Rebeca P. F. Rocha,
  • João Victor da Silva Guerra,
  • Rafael de Felicio,
  • Carolina Moretto Carnieli,
  • Luiza Leme,
  • Antonio Cláudio Padilha,
  • Adriana F. Paes Leme,
  • Daniela B. B. Trivella,
  • Rodrigo Villares Portugal,
  • Paulo Sérgio Lopes-de-Oliveira,
  • Rafael Elias Marques

DOI
https://doi.org/10.1038/s41467-021-23400-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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Mayaro virus (MAYV) is an emerging arbovirus in Central and South America that is transmitted by mosquitoes and causes arthritogenic disease. Here, the authors present the 4.4 Å resolution cryo-EM structure of MAYV and describe specific features of the virus, which could be exploited for the design of MAYV-specific diagnostics and therapeutics.