Changes and significance of serum levels of VEGF, ES, TKLK, TSP and sICAM-1 in patients with diabetic retinopathy

Abstract

AIM: To investigate the changes of serum levels of vascular endothelial growth factor(VEGF), Endostatin(ES), thrombospondin(TSP), tissue kallikrein(TKLK)and soluble intercellular adhesion molecule-1(sICAM-1)in patients with diabetic retinopathy(DR)and its clinical significance. METHODS: Selected 60 patients with non-proliferative diabetic retinopathy(NPDR group), 60 patients with proliferative diabetic retinopathy(PDR group)were enrolled in this study. Sixty diabetic patients without diabetic retinopathy(DM group)and 60 healthy people(control group)were also enrolled. Collection time was from January 2014 to December 2016. Serum levels of VEGF, ES, TSP, TKLK and sICAM-1 were measured and compared. RESULTS: The levels of serum VEGF, TKLK and sICAM-1 in PDR group were significantly higher than those in NPDR group, DM group and control group(PPPPPP>0.05). CONCLUSION: The levels of serum ES, TSP, TKLK and sICAM-1 in patients with DR have changed significantly, and the process of retinopathy has been affected by regulating the level of VEGF.

Keywords

• vascular endothelial growth factor
• endostatin
• platelet reactive protein
• tissue kallikrein
• soluble intercellular adhesion molecule -1
• diabetic retinopathy
• diabetic retinopathy