Nature Communications (Dec 2019)
Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients
- David Michalovich,
- Noelia Rodriguez-Perez,
- Sylwia Smolinska,
- Michal Pirozynski,
- David Mayhew,
- Sorif Uddin,
- Stephanie Van Horn,
- Milena Sokolowska,
- Can Altunbulakli,
- Andrzej Eljaszewicz,
- Benoit Pugin,
- Weronika Barcik,
- Magdalena Kurnik-Lucka,
- Ken A. Saunders,
- Karen D. Simpson,
- Peter Schmid-Grendelmeier,
- Ruth Ferstl,
- Remo Frei,
- Noriane Sievi,
- Malcolm Kohler,
- Pawel Gajdanowicz,
- Katrine B. Graversen,
- Katrine Lindholm Bøgh,
- Marek Jutel,
- James R. Brown,
- Cezmi A. Akdis,
- Edith M. Hessel,
- Liam O’Mahony
Affiliations
- David Michalovich
- Adaptive Immunity Research Unit, GSK R&D
- Noelia Rodriguez-Perez
- Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich
- Sylwia Smolinska
- Department of Clinical Immunology, Wroclaw Medical University
- Michal Pirozynski
- Department of Allergology and Pulmonology, Centre of Postgraduate Medical Education
- David Mayhew
- Computational Biology, Human Genetics, GSK R&D
- Sorif Uddin
- Adaptive Immunity Research Unit, GSK R&D
- Stephanie Van Horn
- Target and Pathway Validation, Target Sciences, GSK R&D
- Milena Sokolowska
- Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich
- Can Altunbulakli
- Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich
- Andrzej Eljaszewicz
- Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich
- Benoit Pugin
- Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich
- Weronika Barcik
- Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich
- Magdalena Kurnik-Lucka
- Department of Pathophysiology, Jagiellonian University Medical College
- Ken A. Saunders
- Adaptive Immunity Research Unit, GSK R&D
- Karen D. Simpson
- Adaptive Immunity Research Unit, GSK R&D
- Peter Schmid-Grendelmeier
- Christine Kühne-Center for Allergy Research and Education (CK-CARE)
- Ruth Ferstl
- Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich
- Remo Frei
- Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich
- Noriane Sievi
- Pulmonary Division, University Hospital of Zurich
- Malcolm Kohler
- Pulmonary Division, University Hospital of Zurich
- Pawel Gajdanowicz
- Department of Clinical Immunology, Wroclaw Medical University
- Katrine B. Graversen
- National Food Institute, Technical University of Denmark
- Katrine Lindholm Bøgh
- National Food Institute, Technical University of Denmark
- Marek Jutel
- Department of Clinical Immunology, Wroclaw Medical University
- James R. Brown
- Computational Biology, Human Genetics, GSK R&D
- Cezmi A. Akdis
- Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich
- Edith M. Hessel
- Adaptive Immunity Research Unit, GSK R&D
- Liam O’Mahony
- Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich
- DOI
- https://doi.org/10.1038/s41467-019-13751-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Here, the authors characterize immunological and microbiome alterations in a cohort of obese asthmatics, finding that disease severity negatively correlates with fecal abundance of Akkermansia muciniphila, and show in a mouse model that administration of A. muciniphila reduces airway hyper-reactivity and airway inflammation.
