Serum vitamin levels in multiple system atrophy: A case-control study

Daji Chen; Linlin Wan; Linlin Wan; Linlin Wan; Linlin Wan; Zhao Chen; Zhao Chen; Zhao Chen; Zhao Chen; Xinrong Yuan; Mingjie Liu; Zhichao Tang; You Fu; Sudan Zhu; Xuewei Zhang; Rong Qiu; Beisha Tang; Beisha Tang; Beisha Tang; Beisha Tang; Hong Jiang; Hong Jiang; Hong Jiang; Hong Jiang; Hong Jiang; Hong Jiang

doi:10.3389/fnagi.2022.1105019

Frontiers in Aging Neuroscience (Jan 2023)

Serum vitamin levels in multiple system atrophy: A case-control study

Daji Chen,
Linlin Wan,
Linlin Wan,
Linlin Wan,
Linlin Wan,
Zhao Chen,
Zhao Chen,
Zhao Chen,
Zhao Chen,
Xinrong Yuan,
Mingjie Liu,
Zhichao Tang,
You Fu,
Sudan Zhu,
Xuewei Zhang,
Rong Qiu,
Beisha Tang,
Beisha Tang,
Beisha Tang,
Beisha Tang,
Hong Jiang,
Hong Jiang,
Hong Jiang,
Hong Jiang,
Hong Jiang,
Hong Jiang

Affiliations

Daji Chen: Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
Linlin Wan: Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
Linlin Wan: Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China
Linlin Wan: Department of Radiology, Xiangya Hospital, Central South University, Changsha, China
Linlin Wan: Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, China
Zhao Chen: Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
Zhao Chen: Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China
Zhao Chen: Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, China
Zhao Chen: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Xinrong Yuan: Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
Mingjie Liu: Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
Zhichao Tang: Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
You Fu: Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
Sudan Zhu: Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
Xuewei Zhang: Health Management Center, Xiangya Hospital, Central South University, Changsha, China
Rong Qiu: School of Computer Science and Engineering, Central South University, Changsha, China
Beisha Tang: Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
Beisha Tang: Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China
Beisha Tang: Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, China
Beisha Tang: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Hong Jiang: Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
Hong Jiang: Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China
Hong Jiang: Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, China
Hong Jiang: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Hong Jiang: School of Basic Medical Science, Central South University, Changsha, China
Hong Jiang: National International Collaborative Research Center for Medical Metabolomics, Central South University, Changsha, China

DOI: https://doi.org/10.3389/fnagi.2022.1105019
Journal volume & issue: Vol. 14

Abstract

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AimThere is increasing evidence suggesting that vitamins may play important roles in the pathogenesis of multiple system atrophy (MSA). The purpose of this study was to detect the changes of serum vitamin levels and investigate their correlation with disease severity in MSA patients.MethodsIn this cross-sectional study, 244 MSA patients, 200 Parkinson’s disease (PD) patients and 244 age-gender matched healthy controls were recruited. Serum vitamin levels were measured, including vitamin A, B1, B2, B9 (folate), B12, C, D, and E. Relevant clinical scales were used to assess the disease severity of MSA patients.ResultsCompared with the healthy controls, decreased serum folate levels and increased serum vitamin A and C levels were detected in MSA patients. Similar differences were also observed in the gender-based subgroup analysis. There were no differences detected between MSA and PD patients. In MSA patients, significant correlation was found between vitamin A, folate, or vitamin C and relevant clinical scales or laboratory findings. In addition, ROC analysis showed potential diagnostic value of the combination of vitamin A, folate, and vitamin C in distinguishing MSA patients from healthy controls.ConclusionThere were significant changes in the blood vitamin spectrums of MSA patients, suggesting that dysregulation of vitamins homeostasis might play an important role in the pathogenesis of MSA.

Published in Frontiers in Aging Neuroscience

ISSN: 1663-4365 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.frontiersin.org/journals/aging-neuroscience

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