Communications Biology (May 2024)
A genome-wide association study identifies a locus associated with knee extension strength in older Japanese individuals
- Shuji Ito,
- Hiroshi Takuwa,
- Saori Kakehi,
- Yuki Someya,
- Hideyoshi Kaga,
- Nobuyuki Kumahashi,
- Suguru Kuwata,
- Takuya Wakatsuki,
- Masaru Kadowaki,
- Soichiro Yamamoto,
- Takafumi Abe,
- Miwako Takeda,
- Yuki Ishikawa,
- Xiaoxi Liu,
- Nao Otomo,
- Hiroyuki Suetsugu,
- Yoshinao Koike,
- Keiko Hikino,
- Kohei Tomizuka,
- Yukihide Momozawa,
- Kouichi Ozaki,
- Minoru Isomura,
- Toru Nabika,
- Haruka Kaneko,
- Muneaki Ishijima,
- Ryuzo Kawamori,
- Hirotaka Watada,
- Yoshifumi Tamura,
- Yuji Uchio,
- Shiro Ikegawa,
- Chikashi Terao
Affiliations
- Shuji Ito
- Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences
- Hiroshi Takuwa
- Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences
- Saori Kakehi
- Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine
- Yuki Someya
- Sportology Center, Juntendo University Graduate School of Medicine
- Hideyoshi Kaga
- Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine
- Nobuyuki Kumahashi
- Department of Orthopedic Surgery, Matsue Red Cross Hospital
- Suguru Kuwata
- Department of Orthopedic Surgery, Shimane University Faculty of Medicine
- Takuya Wakatsuki
- Department of Orthopedic Surgery, Shimane University Faculty of Medicine
- Masaru Kadowaki
- Department of Orthopedic Surgery, Shimane University Faculty of Medicine
- Soichiro Yamamoto
- Department of Orthopedic Surgery, Shimane University Faculty of Medicine
- Takafumi Abe
- The Center for Community-based Healthcare Research and Education (CoHRE), Shimane University
- Miwako Takeda
- The Center for Community-based Healthcare Research and Education (CoHRE), Shimane University
- Yuki Ishikawa
- Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences
- Xiaoxi Liu
- Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences
- Nao Otomo
- Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences
- Hiroyuki Suetsugu
- Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences
- Yoshinao Koike
- Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences
- Keiko Hikino
- Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences
- Kohei Tomizuka
- Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences
- Yukihide Momozawa
- Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences
- Kouichi Ozaki
- Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology
- Minoru Isomura
- The Center for Community-based Healthcare Research and Education (CoHRE), Shimane University
- Toru Nabika
- The Center for Community-based Healthcare Research and Education (CoHRE), Shimane University
- Haruka Kaneko
- Department of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine
- Muneaki Ishijima
- Sportology Center, Juntendo University Graduate School of Medicine
- Ryuzo Kawamori
- Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine
- Hirotaka Watada
- Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine
- Yoshifumi Tamura
- Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine
- Yuji Uchio
- Department of Orthopedic Surgery, Shimane University Faculty of Medicine
- Shiro Ikegawa
- Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences
- Chikashi Terao
- Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences
- DOI
- https://doi.org/10.1038/s42003-024-06108-6
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 9
Abstract
Abstract Sarcopenia is a common skeletal muscle disease in older people. Lower limb muscle strength is a good predictive value for sarcopenia; however, little is known about its genetic components. Here, we conducted a genome-wide association study (GWAS) for knee extension strength in a total of 3452 Japanese aged 60 years or older from two independent cohorts. We identified a significant locus, rs10749438 which is an intronic variant in TACC2 (transforming acidic coiled-coil-containing 2) (P = 4.2 × 10−8). TACC2, encoding a cytoskeleton-related protein, is highly expressed in skeletal muscle, and is reported as a target of myotonic dystrophy 1-associated splicing alterations. These suggest that changes in TACC2 expression are associated with variations in muscle strength in older people. The association was consistently observed in young and middle-aged subjects. Our findings would shed light on genetic components of lower limb muscle strength and indicate TACC2 as a potential therapeutic target for sarcopenia.
