Synthesis and biological activities of some 3-chloro-4-(substituted phenyl)-1-{[2-oxo-2-(5-phenyl-1h-tetrazol-1-yl) ethyl] amino} azetidin-2-one as potential antibacterial agents

Abstract

Some new 3-chloro-4-(substituted phenyl)-1-{[2-oxo-2-(5-phenyl-1Htetrazol1-yl) ethyl] amino} azetidin-2-one have been synthesized from Schiff bases of 5-phenyltetrazole. The Schiff bases were obtained by condensation 2-(5-phenyl-1H-tetrazol-1-yl) acetohydrazide with various aromatic aldehydes. Cyclocondensation of Schiff’s bases with chloroacetylchloride in the presence of triethylamine results in azetidinone derivatives. The structures of the newly synthesized azatidinones were confirmed by FT-IR, 1H NMR, 13C NMR and mass spectral data. All the synthesized compounds have exhibited significant activity against the bacteria and fungi tested.

Keywords

• tetrazole
• azetidinone derivatives
• antibacterial activity
• antitubercular activity